COMPELLING SCIENCE
Expertise
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Cell Biology is a strategic technical resource at Biocogent. Utilizing over 100 years of cumulative expertise in skin, cell and tissue culture, and biochemistry, we have established ourselves as a leader in the understanding of therapeutic indicators for skin treatment products. Our laboratories are equipped to perform everything from standard cell and tissue model assays to custom developed unique bio-assays for specific targets and indicators.
Performance assessments include:
Anti-Aging
Matrix Production
• Stimulation of collagens, GAGs, adhesive proteins
Inhibition of Protease Production
• Tests to determine beneficial effects on levels of damaging enzymes
Inhibition of Protease Activities
• Tests for potential to directly inhibit enzymatic damage
Cell Proliferation & Metabolic Rate Measurements
• Tests of cellular renewal and rejuvenation
Anti-Cellulite
Adipocyte Lipolysis
• Tests for stimulation of fat breakdown
Matrix Production
• Stimulation of collagens, GAGs, adhesive proteins
Anti-Inflammatory
Prevention of Inflammatory Signaling
• Tests of efficacy for inhibiting production of molecules (interleukins, prostaglandins, etc.) that trigger the inflammatory response
Prevention of Inflammatory Tissue Damage
• Inhibition of protease production
• Inhibition of protease activities
• Protection of extracellular matrix
• Prevention of leukocyte recruitment
Antioxidant
Scavenging/Quenching of Oxidant Species
• Tests specific to particular oxidant species: superoxide, singlet oxygen, hydroxyl radical, hypochlorous acid
Prevention of Biological Oxidations
• Tests to demonstrate protection of biological molecules: lipids, proteins, nucleic acids
Protection of Cells vs. Oxidant Stress
• Tests of cell viability under oxidant stress and mitigation of inflammatory oxidant production
Measurement of Total Antioxidant Capacity
• A standardized measure of antioxidant activity for comparative ranking
Pigmentation
Tyrosinase Inhibition
• Estimation of pigmentation control at rate-limiting reaction step
Melanocyte Pigmentation
• Tests integrating all melanocyte functions
Melanoderm Pigmentation
• Tests integrating functions of the epidermal melanin unit
Toxicity
Cytotoxicity to Skin Cells
• Tests to assess integrity of membrane-bound organelles and mitochondrial activity as indices of cyto-static and cyto-toxic effects
