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Biocogent, LLC seeks to present reliable information concerning the composition, properties and use of its products, services and processes. However, all literature and other material concerning any product, service or process or its selection or use is provided WITH NO WARRANTY OF ANY KIND. ALL WARRANTIES OF MERCHANTABILITY AND FITNESS OF PURPOSE ARE DISCLAIMED. Biocogent LLC is not liable for consequential, incidental, or special damages. Nothing should be construed as a recommendation or inducement to infringe any patent. No assumption should be made that all safety or environmental protection measures are indicated, or that other measures may not be required.

 

Ellagicin®, HEDI®, Scavenox®, Volpura®, Tellirictin®, Pleiotanicals®, DermalRx® and MariMoist® are registered trademarks of Biocogent LLC 

LuShield™ is a trademark of Biocogent LLC

Expertise

Cell Biology is a strategic technical resource at Biocogent. Utilizing over 100 years of cumulative expertise in skin, cell and tissue culture, and biochemistry, we have established ourselves as a leader in the understanding of therapeutic indicators for skin treatment products. Our laboratories are equipped to perform everything from standard cell and tissue model assays to custom developed unique bio-assays for specific targets and indicators. 
 
Performance assessments include: 

Anti-Aging

Matrix Production

• Stimulation of collagens, GAGs, adhesive proteins

 

Inhibition of Protease Production

• Tests to determine beneficial effects on levels of damaging enzymes

 

Inhibition of Protease Activities

• Tests for potential to directly inhibit enzymatic damage

 

Cell Proliferation & Metabolic Rate Measurements

• Tests of cellular renewal and rejuvenation

 

Anti-Cellulite

Adipocyte Lipolysis

• Tests for stimulation of fat breakdown

 

Matrix Production

• Stimulation of collagens, GAGs, adhesive proteins

 

Anti-Inflammatory

Prevention of Inflammatory Signaling

• Tests of efficacy for inhibiting production of molecules (interleukins, prostaglandins, etc.) that trigger the inflammatory response

 

Prevention of Inflammatory Tissue Damage

• Inhibition of protease production

• Inhibition of protease activities

• Protection of extracellular matrix

• Prevention of leukocyte recruitment

Antioxidant

Scavenging/Quenching of Oxidant Species

• Tests specific to particular oxidant species: superoxide, singlet oxygen, hydroxyl radical, hypochlorous acid

 

Prevention of Biological Oxidations

• Tests to demonstrate protection of biological molecules: lipids, proteins, nucleic acids

 

Protection of Cells vs. Oxidant Stress

• Tests of cell viability under oxidant stress and mitigation of inflammatory oxidant production

 

Measurement of Total Antioxidant Capacity

• A standardized measure of antioxidant activity for comparative ranking

 

Pigmentation

Tyrosinase Inhibition

• Estimation of pigmentation control at rate-limiting reaction step

 

Melanocyte Pigmentation

• Tests integrating all melanocyte functions

 

Melanoderm Pigmentation

• Tests integrating functions of the epidermal melanin unit

 

Toxicity

Cytotoxicity to Skin Cells

• Tests to assess integrity of membrane-bound organelles and mitochondrial activity as indices of cyto-static and cyto-toxic effects